The package wxwidgets provides CMake integration:

    find_package(wxWidgets REQUIRED)
    target_compile_definitions(main PRIVATE ${wxWidgets_DEFINITIONS} "$<$<CONFIG:DEBUG>:${wxWidgets_DEFINITIONS_DEBUG}>")
    target_include_directories(main PRIVATE ${wxWidgets_INCLUDE_DIRS})
    target_link_libraries(main PRIVATE ${wxWidgets_LIBRARIES})